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Medicina (Kaunas, Lithuania), 57 (7), 669

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Orlistat is suitable for long-term use in individuals with a BMI of 30 or higher or 27 or higher and weight-related conditions

Consider dose reduction if your resting heart rate consistently exceeds 100 BPM, if you experience persistent palpitations or chest discomfort, or if the heart rate increase significantly affects your exercise tolerance

This is especially the case when you want to lose weight or control diabetes

Puerta, E., Surez-Santiago, J