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In addition, prolonged exposure to pharmacologic doses of long-acting GLP-1 RAs induces tachyphylaxis for the effects on gastric emptying, and that is why nausea vanishes quickly after the beginning of treatment in most patients [19]

With respect to the requirement for Mg 2+ in ATP functions, essentially all of the ATP in the cell has Mg 2+ bound to the phosphates

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doi: 10.4049/jimmunol.165.4.2068 134 ArcaroAGregoireCBakkerTRBaldiLJordanMGoffinLet al