review quotes glp 1 A new systematic and meta-regression of GLP-1 drug cessation and % of weight regained >1 year later is looking more positive than a lot of online clips Full paper is open There is an excellent review

Hnzelmann, H

Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis-Brief Report

At the 12mg dose, participants averaged 24.2% body weight reduction over 48 weeks

What this tail actually does in practice Initial binding to the cell surface via electrostatic interactions Internalization through a mixture of: direct translocation (rare but possible with strong polyArg motifs) endocytosis (the dominant route for most CPPs) Partial endosomal escape PolyArg motifs can destabilize endosomal membranes, but escape efficiency varies widely

Peptide YY and other satiety peptides demonstrate clear physiological roles, with early failures attributable to rapid exposure and intolerance rather than to a lack of efficacy, again favoring re-evaluation

The mechanics of oral bioavailability are therefore critical aspects of drug development