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Long-term etanercept therapy favors weight gain and ameliorates cachexia in rheumatoid arthritis patients: roles of gut hormones and leptin

Safety: The Number I Flagged in June In June I called TRIUMPH-1s 11.3% discontinuation rate at 12 mg a number worth watching, and compared it to roughly 67% for tirzepatide 15 mg in SURMOUNT

clinicaltrials.gov/study/NCT05931367

GLP-1 has been reported to improve glucose-dependent insulin action through the G-protein-coupled receptor, GLP-1R (Drucker and Nauck, 2006)

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The best answer is that phase 2 results were dose-dependent and substantial on average, while individual response varied