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Signs include extreme tiredness, light sensitivity, headaches, muscle and joint pain, difficulty thinking/concentrating, mood swings and depression

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Side effects Generally well-tolerated

Notably, metabolic inhibition with ketoconazole or CYP51A1 knockdown can reverse this sensitivity, suggesting a context-dependent role for CYP51A1 in treatment resistance [76]

It was developed in the 1990s, gained FDA approval in 2005 for type 1 and insulin-treated type 2 diabetes research and clinical use, and demonstrated that amylin signaling could be safely engaged in clinical research populations