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Gastrointestinal side effects (nausea, vomiting) may exacerbate dehydration and prerenal acute kidney injury in susceptible patients, requiring hydration counseling

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Therefore, overall, it appears that the diabetogenic risks commonly associated with diuretics are more strongly linked to hydrochlorothiazide (Padwal and Laupacis, 2004

The [Ag(GSH)] + peak was not observed at the beginning of the reaction

Vitamin B12 deficiency may be exacerbated by the use of proton pump inhibitors (PPIs) or histamine-selective H2 receptors (H2RAs), both of which are commonly co-prescribed with metformin