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Once reconstituted with bacteriostatic water, refrigerate and use within 2830 days
Once per discrete injection per date of service is the baseline rule
it's a fundamental principle of chemical stability
It has quickly become popular because of claims that it stimulates healing and decreases inflammation
& Mendes Pinto, I
Tendon and Ligament Repair Moderate to Strong Evidence Evidence Rating: Moderate-Strong (Several animal studies, some independent replication) Research support for musculoskeletal healing is substantial: Achilles tendon injuries Ligament damage (MCL, ACL) Rotator cuff healing General tendinopathy Surgical repair enhancement The FAK-paxillin mechanism and VEGF upregulation provide clear biological rationale for these effects
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