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15 The analysis estimated cost savings derived from the reduced incidence of 10 obesity-related comorbidities when comparing a stable-weight cohort to a cohort achieving a sustained body weight reduction of 1025% (average: 15%) over a 10-year time horizon

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Perimenopause is the transition period leading up to that, and it typically lasts 4-10 years, most commonly starting in your early-to-mid 40s (though some women start experiencing changes in their late 30s)

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And yes, its got the science community watching closely