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Can it cause a "detox reaction"

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Vitamin B12 Benefits If you have a deficiency, B12 supplementation can: Enhance alertness and cognitive function Encourage the synthesis of healthy red blood cells Aid in controlling sleep cycles Bolster the immune system Aid in weight management and boost metabolism

Kim JH, Choi Y, Lee S, Oh MS

This may explain the differences observed between pre-clinical and clinical studies or even discrepancies between different clinical studies

It is exactly why this belongs under medical supervision with regular bloodwork