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It is possible that the increased physical activity that is made possible when people lose substantial amounts of weight could result in the appearance of joint symptoms that were previously masked by inactivity

Methods Linkage Disequilibrium Score Regression (LDSC) was utilized to assess the genetic correlation between T2D and SA

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Change from baseline in A1C was the primary efficacy end point in all LEAD trials

The combination specifically explores whether these non-overlapping mechanisms produce additive or synergistic activity in tissue-repair model systems

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