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Single-cell profiling has identified microglia as key sentinel cells of the gutbrain axis that respond rapidly to intestinal inflammatory cues [13]

However, increased activity may expose underlying spinal issues that were previously unnoticed, especially if someone already has: disc bulges herniated discs degenerative disc disease Not all back pain is disc related, but certain symptoms may suggest nerve pressure or disc involvement

Yamada, T.) 10601062 (Wiley-Blackwell, 2009)

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Given the biological challenges, is long-term weight loss a realistic goal