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Clinical trials have highlighted significant weight reduction in participants without diabetes, with many experiencing a decrease in body weight ranging from 10% to 15% from their baseline over 68 weeks when combined with lifestyle modifications like diet and exercise
doi:10.1073/pnas.0903485106
Neurotherapeutics 7 , 452470 (2010)
Because muscle tissue is metabolically active, losing a significant amount of it contributes to a slower metabolism and, consequently, overall weight gain
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