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THF plays an important role in DNA synthesis, so reduced availability of THF results in ineffective production of cells with rapid turnover, in particular red blood cells, and also intestinal wall cells which are responsible for absorption

Taking it on a "strict empty stomach" (without any carbohydrates) is less effective than taking it with a small carbohydrate intake

If you have diagnosed thyroid disease, it's essential to discuss selenium from food and supplements with your clinician's guidance, as exceeding safe levels can be harmful

Retrieved 7 January 2014

Mild headache or dizziness : This normally passes quickly

Most patients receive initial instruction from a practice nurse or healthcare professional before attempting home administration