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Loss of mitochondrial integrity is a downstream pathology of multiple proposed neurotoxic pathways including intrinsic apoptosis, loss of bioenergetic function and oxidative damage, making mitigation of this convergence point an attractive therapeutic target

Key secondary endpoints, outlined by Jeremy Pettus, MD, Associate Professor of Medicine at the University of California, San Diego, included the proportion of participants achieving the American Diabetes Association (ADA)-recommended A1C target, percent change in body weight, and percent change in total daily insulin dose

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