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These data are consistent with a clear pro-fibrotic paracrine signal originating from the injured, ballooned hepatocyte

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Treatment was well-tolerated, with nausea being the most common side effect (5% discontinuation rate)

This strategy may provide combined benefits beyond single-compound use in research models

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This duality of practice patterns underscores the pressing need for rigorous studies to definitively assess methylene blues safety and efficacy in the treatment of pediatric shock, ultimately guiding physicians towards more informed and effective clinical decisions