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[59] Approval of the original brand-name versions (such as Ozempic) was based on a biologic (recombinant DNA) production process using a genetically-modified yeast ( Saccharomyces cerevisiae ) to produce a precursor to semaglutide, and subsequent chemical processes (protein purification) to create the active ingredient

Homeostasis model assessment of insulin resistance (HoMA-IR) was used as an index of insulin resistance in patients, which was calculated with the following formula: HoMA-IR = FBG (mmol/L) fasting serum insulin (IU/mL)/22.5 (30)

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Small-molecule reactions can be conducted in standard reactor vessels of essentially unlimited size, limited only by heat transfer and mixing considerations

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