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Competing interests: All authors have completed the BMJ Rapid Recommendations interests disclosure form, and a detailed description of all disclosures is reported in appendix 1 on bmj.com

doi: 10.1073/pnas.1108220109 69 PongkanWPintanaHSivasinprasasnSJaiwongkamTChattipakornSCChattipakornN

The SURPASS trials showed that tirzepatide achieved significant HbA1c reductions and was not linked to NPDR progression compared to placebo (178)

If the half-life is five days, you might wonder why the dose isnt given every five days

Diabetologia 59(3):533541

Patients with obesity, or overweight plus a weight-related condition, on the 2.4 mg maintenance dose lost 15% on average (vs ~2%)