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( a - h ) Metabolic phenotype of standard chow-fed lean mice

This is where precision medicine approaches (as touched on) will likely come into play identifying which patients have immune mitochondrial dysfunction via biomarkers and tailoring therapies accordingly

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Importantly, a pilot study in older adults with T2DM and obesity reported that semaglutide preserved the SMM percentage of the extremities despite a decrease in total muscle mass [55]

Common adverse effects include nausea (reported in 20-44% of patients), vomiting, diarrhea, constipation, and abdominal discomfort