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Quick research summary
Traditional oral forms may be poorly absorbed, as glutathione can be broken down by the digestive system before it reaches the bloodstream
The intranasal route was chosen for its ability to bypass the blood-brain barrier, allowing the peptide to reach brain tissue more effectively while minimizing systemic copper exposure
Can peptides improve sperm morphology and DNA integrity
This study demonstrated that cultured hepatocytes treated either with a precursor of GSH, such as L-cysteine or N-acetylcysteine, or with its soluble ethyl ester form, boosts the levels of cellular GSH, which upregulates CYP27A1, CYP27B1, and VDR but downregulates CYP24A1
These integrated actions highlight its clinical relevance for NAFLD management (81)
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