However, HeLa cells are much more sensitive, with 2.5 nM (per million cells) of doxorubicin resulting in up to 80% GSH depletion for the same exposure time 38
Specifically, pathways related to cell division and pluripotency maintenance related pathways were enriched, which is consistent with the results of METTL3 inhibition (Fig
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Glutathione (GSH) and its precursor, cysteine (Cys), are the two most abundant low-molecular weight thiols in living cells, and their intracellular abnormal levels are associated with diseases 1
Peptides are short amino acid chains with 250 molecules that build proteins
The identity of the residues surrounding the pockets of mTYR and hTYR is only 11.8%, with a similarity of 23.5%