semaglutide fda approved for weight loss (wegovy) US FDA accepts Novo Nordisk's

doi:10.1016/j.cmet.2022.07.013 Jastreboff AM, Kaplan LM, Fras JP, et al

I knew it was worth trying this medication and adding it alongside a nutrition and personal training regimen that I had already started

Before we dive into the background science, here is an essential regulatory update

If you're switching to a more potent GLP-1 drug (e.g., semaglutide to tirzepatide), your insulin or sulfonylurea dose may need to decrease

These effects are primarily attributed to its caffeine content rather than any GLP-1-specific mechanism

The mechanisms behind the renoprotective effects of GLP-1 RAs involve anti-albuminuric, anti-inflammatory, natriuresis, anti-atherogenic, and anti-oxidant effects through protein kinase A signaling, induction of natriuresis by inhibiting sodium-hydrogen exchanger 3, and a reduction in hyperfiltration 27,30,31