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& Lin, H
The appearance of a pustular/papular rash associated with high levels of Vitamin B12 is well described in the medical literature even though the exact mechanism appears to be unknown
A deficiency in Vitamin B12 is associated with a significantly increased risk of depression
Microscopically, the treated animals retained more axons and showed less white matter damage
It was reported that BMAL1 deficient mice had altered circadian rhythm of circulating IGF-1 levels (Patel et al., 2016), and CRY1 and 2 deficient mice had reduced IGF-1 production ( Due to the difficulty in measuring pulsatile GH secretion, the interaction between the GH-IGF-1 axis and circadian clock warrants further detailed research
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