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G3-Genes Genomes Genetics 1, 457469.Google ScholarPubMed Kappe, C, Tracy, LM, Patrone, C, Iverfeldt, K and Sjoholm, A (2012) GLP-1 secretion by microglial cells and decreased CNS expression in obesity

2 Cryogenic electron microscopy (CEM) imaging demonstrates that orforglipron binds within the upper helical bundle of GLP-1R and acts as a highly potent partial agonist that favors cyclic adenosine monophosphate (cAMP) signaling over beta-arrestin recruitment