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This is also the time to discuss whether GLP-1 therapy is appropriate or whether another medical weight loss approach may be better
But the therapeutic window narrows sharply the moment you add anything else affecting dopamine, norepinephrine, or serotonin
In the SURMOUNT-1 trial the landmark study of Zepbound in adults without diabetes participants lost an average of: 15% of body weight on 5 mg (~34 lbs) 19.5% of body weight on 10 mg (~44 lbs) 20.9% of body weight on 15 mg (~48 lbs) 3.1% on placebo (with diet and exercise) At the highest dose, 91% of participants achieved weight loss of 5% or more which is the threshold at which meaningful health benefits begin
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For context on how these numbers compare to other dose levels, our tirzepatide dosage chart in units covers every dose from 2.5 mg through 15 mg
See Important Safety Information, including Boxed Warning, at
