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Rather than reflecting a simple imbalance between energy intake and expenditure, obesity represents an actively defended physiological state in which compensatory mechanisms promote weight regain following weight loss attempts ( Among these strategies, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as the most effective anti-obesity pharmacotherapies to date

It lives in the mucus layer of the intestinal lining, where it feeds on mucin, the glycoprotein that forms the protective barrier between gut bacteria and intestinal cells

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