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Two of them (GLP-1 and GIP) are already targets for approved drugs: GLP-1 alone for semaglutide (Ozempic, Wegovy), GLP-1 and GIP together for tirzepatide (Mounjaro, Zepbound)

Streiner, D

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Diabetic retinopathy changes in people with type 2 diabetes

The medication reduces the risk of cardiovascular diseases such as stroke, myocardial infarction, hypertension, and heart failure, and ensures the kidneys get a steady and healthy blood supply

Clinician and Guideline Perspectives on Re-Titration The American Diabetes Association's 2024 Standards of Medical Care in Diabetes state: "GLP-1 receptor agonists should be initiated at low doses and titrated slowly to improve gastrointestinal tolerability." [10] This language applies equally to initial starts and restarts after gaps