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Collectively, these studies imply mutant ALS proteins produce inflammatory cytokines, disturb redox homeostasis, and increase neuroinflammation and toxicity

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Finally, place the mounted slides flat in a well-ventilated area and allow them to dry naturally

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Despite being considered as distinct pathological events, oxidative stress, neuroinflammation and mitochondrial dysfunction interplay with and enhance each other (Picca et al., 2020) (Figure 2)