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A WHO consultation identified the most vulnerable groups as elderly individuals, infants, preschool-aged children, and pregnant or lactating women, due to either increased nutritional demands or impaired absorption capacity ( Addressing the prevention of B12 deficiency and its public health implications requires a comprehensive, life-course approach based on integrated strategies targeting early detection, dietary optimisation, and effective supplementation, in order to mitigate the long-term consequences of inadequate cobalamin status ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits
Other supplements that have been proposed to help include vitamin C, zinc, curcumin (from turmeric), bromelain, collagen and glucosamine
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Its promoter region contains eight stress-responsive cis-acting elements linked to phytohormones and stress pathways, including abscisic acid, MeJA (methyl jasmonate), gibberellin and salicylic acid ( III stress and reduces levels of the lipid peroxidation marker MDA, highlighting its potential as a target for crop improvement ( Arabidopsis , mirroring the function of mammalian CHAC2 (Vernoux et al., 2000)
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