which works faster semaglutide or tirzepatide vs Semaglutide: Weight Loss Drug Is Best Semaglutide vs Tirzepatide: Which Works

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The bottom line Since the earliest days of GLP-1s with exenatide in 2005, through the past two decades to Ozempic and Mounjaro, the field has come a long way and will continue to evolve

Brand name Active drug Indication Approval year Max approved dose Ozempic Semaglutide Type 2 diabetes (glycemic control) 2017 2 mg/week Wegovy Semaglutide Chronic weight management (BMI 30 or 27 + comorbidity) 2021 2.4 mg/week Rybelsus Semaglutide Type 2 diabetes (oral daily tablet) 2019 14 mg/day (oral) Mounjaro Tirzepatide Type 2 diabetes (glycemic control) 2022 15 mg/week Zepbound Tirzepatide Chronic weight management (BMI 30 or 27 + comorbidity) 2023 15 mg/week Table 1 FDA-approved indications for semaglutide and tirzepatide brand names

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Beyond week 12: Doses may increase to 1.7mg or 2.4mg for patients who tolerate lower doses well but need additional appetite suppression