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The Mayo Clinic said the supplement may be safe when taken in recommended amounts with the main side effects including nausea, constipation, diarrhea, gas and vomiting

From there, the patient and doctor will collectively decide if they think its best to increase the dosage or maintain it at 1mg

This makes it difficult to obtain circulating factors that meet the requirements of experimental research and clinical treatment, which affects the accuracy of the research results and the therapeutic effects in the clinic