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Some disulfide intermediates (structure 5, Figure 9) displaying high schistosomicidal activity were shown to act as prodrugs of the pyrrolopyrazine thione (structure 4, Figure 9) [58]
Intriguingly, the emerging trained immunity may provide a possible explanation for non-specific effects
The improvements could be due to placebo effect or the invasive procedure itself (cystoscopy), and subtle side effects might have gone unnoticed in such a small sample
Ann Rheum Dis
S., Caffin, N., Turner, M
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