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Hydration management requires particular attention, as reduced appetite may inadvertently decrease fluid intake
Sardu C, Marfella LV, Fumagalli C, et al
The molecule that emerged from this foundational work carried a disabling flaw as a therapeutic scaffold: native GLP-1 is degraded almost immediately by the serine protease dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between residues 8 and 9 and confers a circulating half-life of under two minutes [4]
Regular follow-up visits can help manage side effects, adjust insulin doses, and ensure the medication is working safely and effectively
Sonia Hernandez-Diaz, senior author of the report published in Annals of Internal Medicine
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