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CYP2E1 variants affect NAPQI production rates
Refined carbohydrates , such as white pasta, white bread, and sugary foods, are rapidly digested and absorbed, causing quick spikes in blood glucose followed by subsequent drops that can trigger hunger
These imbalances can also cause dizziness
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Consumer misconceptions around synthetic formulations and safety concerns also dampen penetration in conservative markets
STEP (semaglutide, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide, NEJM 2022), and SURMOUNT-OSA (NEJM 2024) anchor the class
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