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Though an elevated number of native LDL particles does not directly endanger endothelial cells, it does mean that there are more LDL particles available to become oxidized (or otherwise modified), which then become more likely to damage endothelial cells
Permeability can rise for many reasons
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More recent studies suggest that intermittent, low-dose Rapamycin may delay or prevent age-related conditions by promoting autophagy (cellular cleanup), reducing inflammation, and improving immune function

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