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Thus, adequate folate intake is essential for preventing depression, due to its role in the synthesis of dopamine and serotonin, as well as dementia, through the prevention of neuronal damage (23)

After 52 weeks of treatment, the proportion of participants in the oral semaglutide group achieving an A1C of less than 7.0% was 58.3% (treatment-policy estimand) and 62.8% (trial-product estimand), compared with 25.2% (treatment-policy estimand) and 28.3% (trial-product estimand) for the group receiving 100 mg of sitagliptin daily

Turnbull and Rivier 1995

The CMAJ guidance A guidance article published in the Canadian Medical Association Journal (CMAJ) on glucagon-like peptide-1 receptor agonists during pregnancy and lactation concluded that while the safety data is limited, the pharmacological properties of GLP-1 agonists (large molecular weight, poor oral bioavailability) suggest low theoretical risk during breastfeeding

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MC4R activity also drives arousal and appetite effects [1]
