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Metformin inhibits melanogenesis by reducing intracellular cyclic adenosine monophosphate (cAMP) accumulation, but its low lipophilicity obligates its use in high concentrations for topical efficacy [62]

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Lipid ROS, a classic biomarker of ferroptosis, was accumulated in VRK2-KO cells following APR-017 treatment (Fig

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Since selenium supplementation in the forms of sodium selenite and SeM was well documented to induce the expressions of seleno-GPxs through their metabolic assimilation into bioavailable selenium (hydrogen selenide), the initial studies focused on exploring selenium supplementation as a strategy to achieve protection against radiation-induced toxicity [38, 66]