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The combination of metformin and GLP-1 RAs, via complementary mechanisms and improved leptin sensitivity, translates into greater weight loss success response and reduced GLP-1RA-related adverse events, particularly with concurrent initiation of both agents

More information The Obesity Medicine Association has more on excess weight and sleep apnea

Compelling results from the Phase 2B trial made headlines in December 2025, and now investors are waiting for additional data