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[6] [5] Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation
GLP-1 has been reported to act on neural pathways by acting on areas of the brain with a weak blood brain barrier [18,19,20] and vagal afferent [21,22,23]
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The glucagon receptor activation (paradoxically) adds metabolic benefits when paired with GLP-1 and GIP , such as promoting energy expenditure and fat oxidation, possibly combating the decrease in basal metabolic rate that accompanies weight loss, and helping reduce liver fat
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[42] [114] [115] Herbicide-induced oxidative stress has been experimentally mitigated in vivo in a high-melatonin transgenic rice
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