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For persistent or severe symptoms Any side effect that worsens over time, spreads beyond the application area, or is accompanied by systemic symptoms like fever, malaise, or swollen lymph nodes requires professional evaluation

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Association of macrovascular complications of type 2 diabetes mellitus with serum magnesium levels

The positive effects are ascribed to the elevated concentrations of anthocyanins such as cyanidin-3-O-glucoside that are found in purple corn, which exhibit potent antioxidant characteristics

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So the older "oral does nothing" framing has softened