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7) Kidney Function Generally, renal function has a tendency to decrease as people get older
In the second subgroup (ALC add-on vs the same background drug), Gavrilova et al 19 observed AEs in 35% with ALC add-on versus 45% with antidepressant alone, and Ramezani et al 20 reported AEs in three patients (1 in ALC + sertraline, 2 in sertraline + placebo)
Clinical research, including randomized withdrawal studies of the semaglutide group, shows that individuals who continue treatment while maintaining healthy habits are more likely to sustain their weight loss
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However, effects on plasma markers and steatosis were not significant (except leptin) for either compound in this study
Furthermore, it has demonstrated favorable renal effects, including improvements in eGFR and reductions in the urinary albumin-to-creatinine ratio, reflecting enhanced kidney function [Table 4]
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