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In agreement with this, mutations in PC 1/3 lead to abnormalities in GLP-1 processing and secretion, associated with multiple endocrinopathies (143) (undoubtedly because PC 1/3 is important for processing of many regulatory peptides/hormones), and mice with a targeted deletion of the PC-1/3 gene are unable to process proglucagon to GLP-2 and GLP-1 (295, 344)

L(-)-carnitine production using a recombinant Escherichia coli strain

Maintaining potency over weeks in a depot (and over months/years on the shelf) requires innovative formulation

Peptides and TRT are frequently combined for enhanced results

Acknowledgements PSA is supported by the American College of Medical Genetics Foundation/Genzyme 2014-2015 Fellowship in Biochemical Genetics

Lower tyrosinase activity can reduce melanin production and shift pigment toward lighter forms