The peptide promotes collagen synthesis and breakdown, so in essence it may help the skin recycle old cells to replace them with healthier new ones [2]
In broad terms the published literature associates the first branch more with metabolic and survival readouts and the second more with proliferative ones, but the separation is a tendency rather than a rule and depends heavily on cell background
However, as with any medical treatment, some individuals may experience mild to moderate reactions
This study also connected the differences in activity to the molecular structure of the flavonoids [2]
The mobile phase consisted of component (A) citric acid buffer (50 mM, pH 2) and component (B) acetonitrile/water (90:10 v/v%) and a gradient was applied: 0 min, 0% B
(In essence, FOXO4 holds p53 so it cannot execute the death program)