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Its role is twofold: it promotes satiety, helping you feel full and satisfied on smaller portions, and crucially, it helps preserve lean muscle mass

Clinical trials demonstrate substantial weight loss with both compounds

ELIXA trial included patients with recent cardiovascular event (patients with acute coronary syndrome 180 days before randomization), and although there was no benefit in MACE reduction in lixisenatide treated patients compared to placebo, results revealed cardiovascular safety of lixisenatide in this specific high risk population ( Dose-dependent effect for oral semaglutide was assessed and proven in Japanese PIONEER 9 trial, where greater reduction of HbA1c and weight loss was achieved with higher dose of oral semaglutide compared to placebo and 0.9 mg liraglutide ( Mechanisms related to cardiovascular effects of GLP-1 receptor agonists The cardiovascular effects of GLP-1 receptor agonists in CVOTs can be attributed to several mechanisms

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Water Retention and Bloating IGF-1 LR3 can lead to mild water retention , causing a bloated appearance and in some cases, elevated blood pressure

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