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In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis

(J Orthop Res 2006) demonstrated a significant improvement in the biomechanical strength, stiffness, and elasticity modulus of the Achilles tendon in rats after detachment

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Moderate caloric restriction (15-20% below maintenance) supports AOD-9604 protocols without triggering metabolic adaptation or excessive muscle loss

This minimizes blockage of the nasal membrane and also optimizes absorption