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Mutations in SOD1 can cause familial ALS (several pieces of evidence also show that wild-type SOD1, under conditions of cellular stress, is implicated in a significant fraction of sporadic ALS cases, which represent 90% of ALS patients.), [58] by a mechanism that is presently not understood, but not due to loss of enzymatic activity or a decrease in the conformational stability of the SOD1 protein

Moreover, starving animals can also lower metabolic costs by downregulating both the cellular demand for and the supply of adenosine triphosphate (ATP) 13

Cells 11 (19), 3021 (2022)

Being sleep-deprived doesn't just feel icky, it can also increase inflammation

Acta Biomater

For those interested in B12 for mood and focus, studies suggest a connection between vitamin B12 and neurotransmitters involved in emotional balance and concentration