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Sodium-glucose co-transporter 2 (SGLT2) inhibitor canagliflozin suppresses TECs apoptosis via maintaining metabolic homeostasis (119), while boeravinone C, an PPAR activator/agonist, can alleviate lipid accumulation and inflammation, thereby suppressing tubular apoptosis (120)

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PoekerSAGeirnaertABerchtoldLGreppiAKrychLSteinertREet al

The interaction very rarely results in a pernicious anemia that appears reversible with discontinuation of metformin or with Methylcobalamin, vitamin B12 supplementation