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If there is not enough evidence to rule out potential confounds or other factors that could impact this outcome of having a diagnosis of autism, then we simply can't, in good practice, implement a guideline. In the statement issued by the Food and Drug Administration on the changes, it also notes a missing causal relationship

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The BeNeDuctus , Baby-OSCAR and PDA RCT directly challenged the long-standing rationale of treating PDA in extremely preterm infants to improve outcomes, such as BPD

Acta, Part A 61, 2474 (2005).CrossRefGoogle ScholarPubMed

This typically improves as treatment continues and should be discussed with your healthcare professional if persistent