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GLP-1 is derived from the gut and lowers the risk of hypoglycemia (low blood sugar levels)

Most Common Adverse Events Across the Phase 2 obesity and diabetes programs, the most frequently reported adverse events were gastrointestinal in nature

This is achieved in part through the transcriptional activation of genes such as MMP2 and MMP9, which encode matrix metalloproteinases that degrade extracellular matrix barriers (81), as well as CXCR4, a chemokine receptor important in glioma cell migration along stromal cell-derived factor 1 (SDF-1) gradients

Adverse effects include palpitations, arrhythmias, and increased myocardial oxygen demand