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these changes do not make it a growth-hormone secretagogue, instead they sharply reduce its binding to IGF-binding proteins (IGFBPs), which is what extends its circulating half-life and potency relative to native IGF-1

Semaglutide Hype or Hope: Evidence-based Review in Diabesity

Fish, poultry, and dairy products also contribute smaller amounts

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Key stat: GLP-1 medications accounted for $360.9 million, or 35.7%, of the top 10 prescription linear TV ad spending in H1 2025, according to a July iSpot.tv report

Tirzepatide, with its shorter five-day half-life, shows wider fluctuations