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In a critical review of trials published over the past 15 years (Dalby, 2023) failed to document consistent evidence for the role of the microbiome, as an independent factor, in regulating feed intake, adiposity and body weight in mice, rats and humans

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Other GLP-1-adjacent entrants are at similar stages: plausible biology, modest early signals, and RCTs in flight

4 A meta-analysis of findings from 11 clinical trials (seven that used transcranial direct current stimulation [tDCS], three that used transcutaneous electrical nerve stimulation [TENS], and one that used electroacupuncture of the ear) found electrical stimulation in general reduced Tinnitus Handicap Inventory scores and measures of tinnitus loudness and distress

In most, but not all cases we can achieve 1-2 shades of lightening with combination therapy